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课题组所发展的手性配体TF-BiphamPhos与基于多氢键协同活化策略的氨基-硫脲类有机小分子催化剂被国际化学类工具书Encyclopedia of Reagents for Organic Synthesis (e-EROS)《有机合成试剂百科全书》收录。迄今为止作为通讯联系人在Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Commun., CCS Chem., Chem. Sci.等学术期刊发表科研论文120余篇。

欢迎感兴趣的同学和我们联系、加入我们课题组！同时也欢迎本科生到实验室开展业余科研活动！

代表成果

1. Chang, X.; Cheng, X.; Liu, X. T.; Fu, C.; Wang, W. Y.; Wang, C. J., Stereodivergent Construction of 1,4-Nonadjacent Stereocenters via Hydroalkylation of Racemic Allylic Alcohols Enabled by Copper/Ruthenium Relay Catalysis.Angew. Chem. Int. Ed.2022,61, e202206517.

2. Xiao, L.; Wei, L.; Wang, C. J., Stereodivergent Synthesis of Enantioenriched gamma-Butyrolactones Bearing Two Vicinal Stereocenters Enabled by Synergistic Copper and Iridium Catalysis.Angew. Chem. Int. Ed.2021,60, 24930-24940.

3. Che, C.; Li, Y.-N.; Cheng, X.; Lu, Y.-N.; Wang, C.-J., Visible-Light-Enabled Enantioconvergent Synthesis of α-Amino Acid Derivatives via Synergistic Brønsted Acid/Photoredox Catalysis.Angew. Chem. Int. Ed.2021,60, 4698-4704.

4. Chang, X.; Yang, Y.; Shen, C.; Xue, K.-S.; Wang, Z.-F.; Cong, H.; Tao, H.-Y.; Chung, L. W.; Wang, C.-J., β-Substituted Alkenyl Heteroarenes as Dipolarophiles in the Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides Empowered by a Dual Activation Strategy: Stereoselectivity and Mechanistic Insight.J. Am. Chem. Soc.2021,143, 3519-3535.

5. Wei, L.; Chang, X.; Wang, C.-J., Catalytic Asymmetric Reactions with N-Metallated Azomethine Ylides.Acc. Chem. Res.2020,53, 1084-1100.

6. Xu, S.-M.; Wei, L.; Shen, C.; Xiao, L.; Tao, H.-Y.; Wang, C.-J., Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction.Nat. Commun.2019,10, 5553.

7. Wei, L.; Zhu, Q.; Xiao, L.; Tao, H.-Y.; Wang, C.-J., Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides.Nat. Commun.2019,10, 1594.

8. Wei, L.; Zhu, Q.; Xu, S.-M.; Chang, X.; Wang, C.-J., Stereodivergent synthesis of α,α-disubstituted α-amino acids via synergistic Cu/Ir catalysis.J. Am. Chem. Soc.2018,140, 1508-1513.

9. Wei, L.; Xu, S.-M.; Zhu, Q.; Che, C.; Wang, C.-J., Synergistic Cu/Pd catalysis for enantioselective allylic alkylation of aldimine esters: Access to α,α-disubstituted α-amino acids.Angew. Chem., Int. Ed.2017,56, 12312-12316.

10. Yao, L.; Zhu, Q.; Wei, L.; Wang, Z.-F.; Wang, C.-J., Dysprosium(III)-Catalyzed Ring-Opening of meso-Epoxides: Desymmetrization by Remote Stereocontrol in a Thiolysis/Elimination Sequence.Angew. Chem., Int. Ed.2016,55, 5829-5833.

11. Huang, R.; Chang, X.; Li, J.; Wang, C.-J., Cu(I)-Catalyzed Asymmetric Multicomponent Cascade Inverse Electron-Demand Aza-Diels-Alder/Nucleophilic Addition/Ring-Opening Reaction Involving 2-Methoxyfurans as Efficient Dienophiles.J. Am. Chem. Soc.2016,138, 3998-4001.

12. Li, J.; Huang, R.; Xing, Y.-K.; Qiu, G.; Tao, H.-Y.; Wang, C.-J., Catalytic Asymmetric Cascade Vinylogous Mukaiyama 1,6-Michael/Michael Addition of 2-Silyloxyfurans with Azoalkenes: Direct Approach to Fused Butyrolactones.J. Am. Chem. Soc.2015,137, 10124-10127.

13. Teng, H.-L.; Yao, L.; Wang, C.-J., Cu(I)-Catalyzed Regio- and Stereoselective [6 + 3] Cycloaddition of Azomethine Ylides with Tropone: An Efficient Asymmetric Access to Bridged Azabicyclo[4.3.1]decadienes.J. Am. Chem. Soc.2014,136, 4075-4080.

14. Li, Q.-H.; Wei, L.; Wang, C.-J., Catalytic Asymmetric 1,3-Dipolar [3 + 6] Cycloaddition of Azomethine Ylides with 2-Acyl Cycloheptatrienes: Efficient Construction of Bridged Heterocycles Bearing Piperidine Moiety.J. Am. Chem. Soc.2014,136, 8685-8692.

15. Tong, M.-C.; Chen, X.; Li, J.; Huang, R.; Tao, H.; Wang, C.-J., Catalytic asymmetric synthesis of [2,3]-fused indoline heterocycles through inverse-electron-demand aza-Diels-Alder reaction of indoles with azo-alkenes.Angew. Chem., Int. Ed.2014,53, 4680-4684.

16. He, Z.-L.; Teng, H.-L.; Wang, C.-J., Fulvenes as Effective Dipolarophiles in Copper(I)-Catalyzed [6+3] Cycloaddition of Azomethine Ylides: Asymmetric Construction of Piperidine Derivatives.Angew. Chem., Int. Ed.2013,52, 2934-2938.

17. Liu, T.-L.; Wang, C.-J.; Zhang, X., Synthesis of chiral aliphatic amines through asymmetric hydrogenation.Angew. Chem., Int. Ed.2013,52, 8416-8419.

18. Tong, M.-C.; Chen, X.; Tao, H.-Y.; Wang, C.-J., Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Two Different Ylides: Facile Access to Chiral 1,2,4-Triazinane Frameworks.Angew. Chem., Int. Ed.2013,52, 12377-12380.

19. Xue, Z. Y.; Li, Q. H.; Tao, H. Y.; Wang, C. J., A facile Cu(I)/TF-BiphamPhos-catalyzed asymmetric approach to unnatural alpha-amino acid derivatives containing gem-bisphosphonates.J. Am. Chem. Soc.2011,133, 11757-11765.

20. Wang, C.-J.; Dong, X.-Q.; Zhang, Z.-H.; Xue, Z.-Y.; Teng, H.-L., Highly anti-selective asymmetric nitro-Mannich reactions catalyzed by bifunctional amine-thiourea-bearing multiple hydrogen-bonding donors.J. Am. Chem. Soc.2008,130, 8606-8607.

21. Wang, C.-J.; Liang, G.; Xue, Z.-Y.; Gao, F., Highly Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides Catalyzed by Copper(I)/TF-BiphamPhos Complexes.J. Am. Chem. Soc.2008,130, 17250-17251.

获奖与荣誉

1. 2016年获得中国化学会青年手性化学奖

2. 2015年获得国家杰出青年科学基金

3. 2013年获得Thieme杂志社Synthesis/Synlett Journals Award

4. 2013年入选买球最好的网站珞珈特聘教授

5. 2010年入选教育部新世纪优秀人才支持计划

6. 2009、2011、2013年度三次获得蓝月亮优秀研究生导师奖